Mano Po Legacy: Her Big Boss

Mano Po Legacy: Her Big Boss is a 2022 Philippine television drama romantic comedy series broadcast by GMA Network. The series is the second installment of Mano Po Legacy. It stars Bianca Umali, Ken Chan and Kelvin Miranda. It premiered on March 14, 2022 on the network's Telebabad line up.

• Easy FerrerDirector

• Bianca UmaliIrene Pacheco / Iris Pachingco
• Ken ChanRichard Lim
• Kelvin MirandaNestor Lorenzo
• PokwangBecca Pacheco
• Ricardo CepedaAlex Lim
• Marina BenipayoElaine Lim
• Teejay MarquezRaven Lim
• Sarah EdwardsPrincess Grace Que
• Sarah HolmesRachel Lim