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Dr. Amy Larsen must navigate an unfamiliar world after a brain injury erases the last eight years of her life. She can rely only on her estranged 17-year-old daughter, whom she remembers as a 9-year-old, and a handful of devoted friends, as she struggles to continue practicing medicine, despite having lost nearly a decade of knowledge and experience.

• Molly ParkerDr. Amy Larsen
• Omar MetwallyDr. Michael Hamda
• Amirah VannDr. Gina Walker
• Jon EckerDr. Jake Heller
• Anya BanerjeeDr. Sonya Maitra
• Charlotte Fountain-JardimKatie Hamda
• Patrick WalkerDr. Theodore 'TJ' Coleman
• Felicity HuffmanDr. Joan Ridley