IMPACT Wrestling: Against All Odds 2021

Against All Odds was a professional wrestling event produced by Impact Wrestling. It took place on June 12, 2021, and air exclusively on Impact Plus. It was held at Skyway Studios in Nashville, Tennessee, except for the main event, which was held at Daily's Place in Jacksonville, Florida. It was the 10th event under the Against All Odds chronology and the first to be held since the 2019 event.

• Tyson SmithKenny Omega
• Quinn OjinnakaMoose
• Samuel Alton JohnstonSami Callihan
• Donald CallisDon Callis
• Nicholas MassieNick Jackson
• Matthew MassieMatt Jackson
• Scott D'AmoreScott D'Amore
• Deonna KuprykDeonna Purrazzo
• Holly LetkemanRosemary
• Christopher GrayDeaner
• Terry GerinRhino
• Black TaurusBlack Taurus